医科学コース:基礎医学関連

Molecular Parasitology and RNA Molecular Biology : 寄生虫分子生物学 

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HO Kiong  kiongho(at-mark)md.tsukuba.ac.jp

http://www.md.tsukuba.ac.jp/basic-med/kiongho/Ho_Lab/Welcome.html

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研究室紹介

A primary research interest is to understand the gene expression in protozoan parasites that responsible for major public health concerns, such as Malaria and sleeping sickness disease, with a goal in identifying parasite-specific processes that can be exploited as targets for novel therapeutic interventions. Analysis of mRNA cap formation in these parasite suggest that capping enzyme is an attractive target for anit-protozoan drug development because the mechanism of cap formation is completely different between the parasite and the human host. Second research area aim to understand how damages in the RNAs are recognized and repaired in the cells. One of the few facts that have been established is that RNA ligase – an enzyme that joins the two ends of RNA together – is a key component of this repair process. Understanding of the function and mechanism behind cellular responses to RNA damage may also provide useful therapeutic targets, as breakage in the RNA accumulate in cancer cells and during stress condition.

研究室紹介動画