演題:Oxidative Metabolism and Cardiac Regeneratio
(酸素代謝と心臓再生)
演者:木村 航 先生
(テキサス大学サウスウエスタンメディカルセンター 内科 心臓病学部門/筑波大学 生命領域学際研究センター)
日時:2016年5月13日(金)17:00-18:30
会場:医学系学群棟 4階 4A411会議室
要旨:
The adult mammalian heart is not capable of meaningful functional recovery after substantial loss of myocardium due to an inability of cell division in vast majority of cardiomyocytes. In contrast, some lower vertebrates and immature mammals are capable of full cardiac regeneration through proliferation of pre-existing cardiomyocytes. Therefore, there has been an intense interest in understanding the mechanisms of cardiomyocyte cell cycle regulation, and what distinguishes proliferative cardiomyocyte from terminally-differentiated non-proliferative cardiomyocytes. We have recently demonstrated that a metabolic switch that takes place immediately after birth from glycolysis to oxidative phosphorylation causes cell cycle arrest in mammalian cardiomyocytes through mitochondrial ROS generation (1). In addition, we identified a rare population of cycling cardiomyocytes that are hypoxic and therefore protected from highly oxidative mitochondrial ROS in the adult heart (2). Based on these findings, we propose that oxidative metabolism and redox regulation may hold a key for cardiac regeneration through the induction of cardiomyocyte cell cycle re-entry.

References: (1) Cell 157, 565-579 (2014), (2) Nature 523, 226-230 (2015)

* This seminar will be given in English. *

連絡先:筑波大学生命領域学際研究センター 柳沢裕美 <hkyanagisawa@tara.tsukuba.ac.jp>

*TSMMセミナーは、フロンティア医科学専攻(修士)「医科学セミナーII」(担当:久武幸司)、
生命システム医学専攻 &疾患制御医学専攻(博士)「最先端医学研究セミナー」(担当:熊谷嘉人、島野仁)
及び「医学セミナー」(担当:専攻各教員)の関連セミナーに相当します。

【筑波分子医学協会(TSMM)】HPhttp://www.md.tsukuba.ac.jp/public/tsmm/
TSMMセミナー担当 筑波大学医学医療系 塩見健輔(kshiomi@md.tsukuba.ac.jp)

University of Tsukuba: Ph.D. Program in Human Biologyさんの写真