2012年 パブリケーション情報まとめ

 

環境医学分野(環境生物学)

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原著論文

 

Shinkai Y, Kaji T.
Cellular defense mechanisms against lead toxicity in the vascular system.
Biol Pharm Bull. 2012;35(11):1885-91.  PubMed

 

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Hirose R, Miura T, Sha R, Shinkai Y, Tanaka-Kagawa T, Kumagai Y.
A method for detecting covalent modification of sensor proteins associated with 1,4-naphthoquinone-induced activation of electrophilic signal transduction pathways.
J Toxicol Sci. 2012;37(5):891-8.  PubMed / Online Paper

 

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Kanda H, Toyama T, Shinohara-Kanda A, Iwamatsu A, Shinkai Y, Kaji T, Kikushima M, Kumagai Y.
S-Mercuration of rat sorbitol dehydrogenase by methylmercury causes its aggregation and the release of the zinc ion from the active site.
Arch Toxicol. 2012 Nov;86(11):1693-702.  PubMed

 

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Nishida M, Sawa T, Kitajima N, Ono K, Inoue H, Ihara H, Motohashi H, Yamamoto M, Suematsu M, Kurose H, van der Vliet A, Freeman BA, Shibata T, Uchida K, Kumagai Y, Akaike T.
Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration.
Nat Chem Biol. 2012 Aug;8(8):714-24.  PubMed / Online Paper

 
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Shinkai Y, Iwamoto N, Miura T, Ishii T, Cho AK, Kumagai Y.
Redox cycling of 1,2-naphthoquinone by thioredoxin1 through Cys32 and Cys35 causes inhibition of its catalytic activity and activation of ASK1/p38 signaling.
Chem Res Toxicol. 2012 Jun 18;25(6):1222-30.  PubMed / Online Paper

 
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Yamada H, Akahoshi N, Kamata S, Hagiya Y, Hishiki T, Nagahata Y, Matsuura T, Takano N, Mori M, Ishizaki Y, Izumi T, Kumagai Y, Kasahara T, Suematsu M, Ishii I.
Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine γ-lyase, an animal model of cystathioninuria.
Free Radic Biol Med. 2012 May 1;52(9):1716-26.  PubMed

 
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Kumagai Y, Shinkai Y, Miura T, Cho AK.
The chemical biology of naphthoquinones and its environmental implications.
Annu Rev Pharmacol Toxicol. 2012;52:221-47.  PubMed / Online Paper

 
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総説(和文)

 

「環境中親電子リガンドの細胞内侵入とそれに伴うシグナル伝達の模倣および攪乱.」
実験医学「活性酸素・ガス状分子による恒常性制御と疾患」30: 70-75, 2012
熊谷嘉人
 

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「GAPDHの功罪.」
細胞工学「活性酸素シグナル制御とレドックスホメオスタシス」131: 196-197, 2012
熊谷嘉人

 

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